Use the article I send you, 2-3pages, 4 questions below
Instructions:
Read this paper by Bonafont et al (2019) , and answer the following questions that evaluate the methods and purpose of the study:
1. CRISPR/Cas-9 was used to edit a specific region of DNA, what was the purpose of editing that specific region? Hint: the edit achieved two things as is explained and depicted in Figure 1, what were these two things?
2. For any gene-editing to be useful, especially for use as a therapy, it needs to be precise (i.e. it should edit the intended region, not some other region of the gene). Summarize what steps the authors took to determine how precise their editing was.
3. How did the authors assess the efficacy with which the desired region was edited? (hint: they used at least 2 different ways to make this determination).
4. After creating the keratinocytes with the intended gene edits, what steps were taken to determine if the cells could actually fulfil the intended function when grafted on to the mice? If translated to the clinic, this procedure would involve obtaining patient keratinocytes and grafting the edited keratinocytes back on to the patients skin. What are some features of the process described in the paper that make it favorable for potential use on patients? What are aspects of the process that may still need further studies before being used on patients?
We confidently assure you of high-quality work. We engage a number of strategies in to guarantee top-level assignments. The projects go through a thorough system of control prior to being submitted to the customers. Studentscoursework.com guarantees that the assignments delivered are 100 percent plagiarism-free.
We never share or resell customer’s work. Therefore, once it is checked using our plagiarism software, the assignment will be original. In terms of assignment completion, we adhere to the guidelines given by you and assign the work to the most suitable writer. We assign our writers based on various factors such as academic qualification, previous customer feedback, etc.
First and foremost, we provide high-quality work. However, in case you require extra-brilliance, here is what you can do. First, select a top writer who is proficient in a certain discipline. Second, you can seek our editing services.
Our team of editors revises the assignments, checking them to ensure they comply with the standards of academic writings. Additionally, editing may entail refining the language, adding more reference material, and making sure the formatting part is properly done. The editors may also enhance papers completed by yourself in to meet your needs.
We guarantee the following quality in our work to you:
We use the following tools to crosscheck our assignments:
Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.
You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.
Read moreEach paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.
Read moreThanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.
Read moreYour email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.
Read moreBy sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.
Read more